Epidermis Layers is the relatively thin, tough, outer layer of the skin. Most of the cells in the epidermis are keratinocytes. They originate from cells in the deepest layer of the epidermis called the basal layer. The epidermis (along with other layers of the skin) also protects the internal organs, muscles, nerves, and blood vessels against trauma. The outermost portion of the epidermis, known as the stratum corneum, is relatively waterproof and, when undamaged, prevents most bacteria, viruses, and other foreign substances from entering the body. The epidermis also contains Langerhans cells, which are part of the skin’s immune system.
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