Gout and Hyperuricemia Disease
Hyperuricemia may be an asymptomatic condition, with an increased serum uric acid concentration as the only apparent abnormality. A urate concentration greater than 7.0 mg/dL is abnormal and associated with an increased risk for gout.
In humans, uric acid is the end product of the degradation of purines. It serves no known physiologic purpose and therefore is regarded as a waste product. The size of the urate pool is increased severalfold in individuals with gout. This excess accumulation may result from either overproduction or underexcretion.
The purines from which uric acid is produced originate from three sources: dietary purine, conversion of tissue nucleic acid to purine nucleotides, and de novo synthesis of purine bases.
Uric acid may also be overproduced as a consequence of increased breakdown of tissue nucleic acids, as with myeloproliferative and lymphoproliferative disorders.
Patients may be advised to reduce their intake of foods high in purines (e.g., organ meats), avoid alcohol, and lose weight if obese.