Kaposis Sarcoma

Sunday, April 27th 2014. | Cancer

Kaposis Sarcoma

Kaposis Sarcoma are a cancer that causes brown, purple, or bluish-red tumours that causes patches of abnormal tissue to grow under the skin, in the lining of the throat, nose, and mouth or in other organs.
 
Kaposi sarcoma can be primarily categorized into 4 types:
 
  1. Epidemic of AIDS-related
  2. Immunocompromised
  3. Classic, or sporadic
  4. Endemic (African)
 
Diagnosa of Kaposis Sarcoma :
 
Kaposi’s sarcoma may also appear as lesions on the palate mouth, tonsils, tongue, gums, or as gastrointestinal (stomach or intestine) lesions that bleed. There may also be lesions on the lungs, which may look like an infection or other forms of lung cancer.
 
Other symptoms connected with Kaposi’s sarcoma include:
  • Swollen lymph nodes
  • Difficulty breathing
  • Blood in the sputum
 
Treatment of Kaposis Sarcoma :
 
– Antiretroviral therapy
HAART (highly active antiretroviral therapy) is an integral part of successfull KS therapy. HAART may be tried as the sole modality in nonvisceral disease. For visceral disease, chemotherapy may be added.
 
 
– Immunomodulation
Immunomodulation with interferon-alfa has clinical activity in Kaposi sarcoma that may be mediated by its antiviral, immunomodulatory properties and antiangiogenic.
 
 
– Local therapy 
It could be used for palliation of locaaly advanced symptomatic disease :
  • Laser therapy
  • Surgical excision
  • Topical retinoids
  • Radiation therapy
  • Cryotherapy
  • Intralesional vinca alkaloid therapy
– Combination therapy
ABV (bleomycin, vincristine, and actinomycin D) produces higher response rates than does single-agent therapy (such as doxorubicin), but time to progression and overall survival rates are similar.
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