Skin Cancer – The Need For Vitamin A
Vit A might be essential for cancer of the skin protection. Your skin and mucosal cells (cells that line the airways, digestive system, and urinary system) be the barrier and make up the bodys first type of defense against infection. Retinol (vit a) and it is metabolites (e.g. beta carotene that is transformed into vit a) are needed to keep the integrity and performance of those cells. (Proceedings from the Diet Society. 1999).
n 1999 Scientists in the College of Michigan reported that ultraviolet irradiation in the sun leads to a major lack of retinoic acidity receptors in skin cells. They came to the conclusion that ultraviolet irradiation leads to a vit a deficiency that could have dangerous effects on skin function, adding to premature aging of your skin and the development of cancer of the skin. (Character Medicine 1999 5(4): 418-422).
n 2001 scientists in the College of Texas, Baylor College of drugs and also the College of Arizona checked out the results of exposure to the sun and retinoic acidity (vit a) receptors in skin cells.
The research examined these effects with regards to squamous skin carcinogenesis (SCC) (the procedure through which normal cells are changed into cancer cells).
They observed a progressive reduction in retinoic acidity (vit a) receptors from normal skin to precancerous skin advancing to invasive skin SCC (squamous cell carcinogenesis).
Their results indicate the suppression of retinoid (vit a) receptors happens at the start of the precancerous stage and it is connected with advancement of squamous skin carcinogenesis (the development of cancer). (Cancer Res, 61: 4306-10, 2001).
Swedish scientists, confirming within the journal Experimental Skin care in 2003, used cultured normal human keratinocytes and melanocytes (skin cells) to look at the results of Ultra violet irradiation around the primary retinoid receptors within the our skin.
The keratinocyte may be the major cell type on the skin (surface of skin), creating about 90% of skin cells. Melanocytes are cells situated towards the bottom layer from the skins epidermis.
The authors came to the conclusion that the depletion of vit a and retinoid receptors, and various other factors, by ultraviolet (Ultra violet) irradiation might seriously hinder retinoid (vit a) signalling and for that reason promote future tumor development, particularly in keratinocytes (see above). (Exp Dermatol. 2003 Oct12(5):563-71).
In 1993 Edes along with a friend in the Harry S. Truman Memorial Veterans Matters Hospital, Columbia, Missouri, reported inside a review that contact with benzopyrene, a carcinogen (cancer leading to substance) causes vit a depletion in uncovered tissue.
They noted the effect is obvious during a vit a sufficient diet but considerably, with no loss of serum (bloodstream) Vit A. Quite simply, benzopyrene depleted vit a even if your diet was sufficient within the vitamin, which depletion isn’t apparent in bloodstream tests.
Benzopyrene also called benzo(a)pyrene can be found in coal tar, in automobile exhaust fumes (especially from diesel engines), cigarettes, as well as in charbroiled food. Recent reports have says amounts of benzopyrene in burnt toast are considerably greater than once thought, even though it is misguided whether burnt toast is itself cancer causing. (Wikipedia).
Looking at the studies up to now they observed that although these studies involved nutritional consumption of benzopyrene, it might be realistic to surmise tobacco smoke exposure would have the identical effect. (Ann N Y Acad Sci. 1993 May 28686:203-11 discussion 211-2. Review).